The Healthy Nevada Project and dri research

Researchers at the Healthy Nevada Project and DRI are hard at work analyzing and interpreting genetic, medical, environmental, and socio-economic data from tens of thousands of research participants to help solve complex problems. Without the contributions from our fellow Nevadans, this research would not be possible.  Thank you to all of our Healthy Nevada Project participants for your continuing support of our research endeavors.

Peer-reviewed publications

  1. Bonneford A, Boissel M, Bolze A, et al. 2020. Pathogenic variants in actionable MODY genes associate with type 2 diabetes. Nat. Metabolism. (in press).
  2. Read RW, Schlauch KA, Elhanan G., Metcalf WJ, Slonim AD, Aweti R, Borkowski R, Grzymski JJ. 2019. GWAS and PheWAS of red blood cell components in a Northern Nevadan cohort. PLoS ONE 14, e0218078.
  3. Grzymski, JJ, Elhanan, G, Morales Rosado, JA. et al. Population genetic screening efficiently identifies carriers of autosomal dominant diseases. Nat Med 26, 1235–1239 (2020).
  4. Cirulli, ET. et al. Genome-wide rare variant analysis for thousands of phenotypes in over 70,000 exomes from two cohorts. Nat Commun 11, 542–10
  5. Schlauch, KA. et al. A Comprehensive Genome-Wide and Phenome-Wide Examination of BMI and Obesity in a Northern Nevadan Cohort. G3 10, 645–664.
  6. Rosenquist N, Metcalf J, Ryu SY, Field-Ridley A, Coppes MJ, Grzymski JJ, Strickland MJ, Darrow LA. 2020 Acute associations between PM2.5 and ozone concentrations and asthma exacerbations among patients with and without allergic comorbidities, Journal of Exposure Science & Environmental Epidemiology.
  7. Kiser D, Metcalf WJ, Elhanan G, Schnieder B, Schlauch K, Joros A, Petersen C, Grzymski JJ. 2020. Particulate matter and emergency visits for asthma: a time-series study of their association in the presence and absence of wildfire smoke in Reno, Nevada, 2013-2018. Environ Health 19,

Publications submitted

  1. Bolze A, Mendez F, White S, Tanudjaja F, Isaksson M, Rashkin M, Bowes J, Cirulli ET, Metcalf WJ, Grzymski JJ, Lee W, Lu JT, Washing NJ. Selective constraints and pathogenicity of mitochondrial DNA variants inferred from a novel database of 196,554 unrelated individuals. doi: Also submitted to Nature Genetics.
  2. Field-Ridley A, Rosenquist N, Elhanan G, Joros A, Metcalf J, Coppes M, Strickland M, Darrow L: Exposure to fine particulate matter is associated with health care utilization among infants and children with bronchiolitis, submitted.
  3. Read RW, Lombardi VC, Elhanan G, Metcalf WJ, Slonim A, Schlauch KA, Grzymski JJ, 2019 Genome-wide identification of rare and common variants driving triglyceride levels in a Nevada population. Submitted to Journal of Lipid Research.


  1. Grzymski J, Slotnick N, Rowan C, Elhanan G, Reed H, Lipp B, Smith E, Metcalf J, Bolze A, Dunaway K, Washington N, Lu J. 2019. American College of Medical Genetics. Population Health Genetic Screening in Northern Nevada: At-Risk Individuals are Missed Using Current Guidelines .
  2. Schlauch KA, Read RW, Metcalf J, Elhanan G, Rybarski S, Grzymski J. 2018. American Society of Human Genetics. Published and novel human associations of blood cell traits in the Healthy Nevada Project cohort .
  3. Gai Elhanan, William J Metcalf, Harry Reed, Bruce Lipp, Elizabeth Smith, Nicole Washington, Keith Dunaway, Alex Bolze, Chris Rowan, Nathan Slotnick, James Lu, Joseph J. Grzymski. American Society of Human Genetics 2019. Population-based Genetic Screening: Does diagnostic information enter into the medical record?
  4. J. Rowan, MD, W. J. Metcalf, MSc, G. Elhanan, MD, A. N. Joros, MSc, J. J. Grzymski, PhD. American Thoracic Society 2018. Short-Term Sentinel Air Events in Relation to Health Care Utilization for Specific Health Conditions in Reno, Nevada.
  5. Bolze, S. White, E.T. Cirulli, L. Sharma, K.A. Schlauch, G. Elhanan, J. Grzymski, N.L. Washington, J. Lu. American Society of Human Genetics 2019. A genetic retrospective study of maturity-onset diabetes of the young (MODY) in two population health studies.
  6. T. Cirulli, S. White, R.W. Read, G. Elhanan, W.J. Metcalf, K.A. Schlauch, J.J. Grzymski, J. Lu, N.L. Washington. American society of Human Genetics 2019. Genome-wide rare variant analysis for thousands of phenotypes in 70,000+ exomes.
  7. RW Read, KA Schlauch, ET Cirulli, NL Washington, S White, J Lu, A Slonim, JJ Grzymski. American Society of Human Genetics 2019. Validation and discovery of BMI-related variants in a Northern Nevada cohort of the Healthy Nevada Project.
  8. J. Grzymski, R.W. Read, G. Elhanan, W.J. Metcalf, K.A. Schlauch, A. Slonim. American Society of Human Genetics 2019. A phenome-wide and genome-wide analysis of triglyceride levels in the Healthy Nevada Project cohort
  9. A. Schlauch, R.W. Read, E.T. Cirulli, S. White, N.L. Washington, J. Lu, A. Slonim, J.J. Grzymski. American society of Human Genetics 2019. The genetics of addiction in a large Northern Nevada cohort of the Healthy Nevada Project.
  10. Rosenquist, N, Metcalf J, Elhanan G, Grzymski J, Joros A, Field-Ridley A, Coppes MJ, Strickland, M, , Darrow L: Acute associations between PM5 and allergic and nonallergic asthma exacerbations in children and adults. Presented at the ISES-ISEE 2018 Joint Annual Meeting in Ottawa, August 26-30 2018, Ottawa, Canada.
  11. Field-Ridley A; Metcalf J, Elhanan G, Joros A, Coppes MJ, Strickland, M, Rosenquist, N, Darrow L: Atmospheric temperature inversions are associated with increased burden of pediatric respiratory diseases. Presented at the annual PAS meeting, May 5th 2018, Toronto, Canada.
  12. Miceli, DP. American Association of Geographers 2018 Annual Meeting. Exploratory Ecological Analysis of Opioid Mortality in the United States between 2013 and 2015.
  13. Ward KA, Porath A, Gillespie D, Clodfelter S, Metcalf WJ. Retrospective review of administration patters for intravenous (IV) hydromorphone before and after modification of pain order sets within a regional medical center. American Society of Hospital Pharmacists 2018.


  1. 1R01ES030948-01 Influence of germline mutations on susceptibility to environmental carcinogens. PIs Carbone M, Grzymski J, Yang H. 08/15/2019 – 06/30/2022, $990,000 (DRI).
  2. IRP, Internal DRI Research Grant, Finding rare variants in a specific class of obesity within the Healthy Nevada Cohort. R Read and K Schlauch, 01/01/2019 – 12/01/2020, $24,000.
  3. R01ES029528-01A1 Associations of smoke from wildfires and prescribed burns and cardiorespiratory health outcomes in Reno, NV. Strickland, M, Khlystov A, Samburova V, Metcalf J, 4/01/2019 -03/31/2024, $1,449,717 (DRI).
  4. Renown Health, Services Agreements (multiple); 04/01/2016 – 06/30/2022, $11,473,697.