NEWS & PUBLICATIONS

Publications focused on Population Genetics

1. Schlauch KA, Kulick D, Subramanian K, De Meirleir KL, Palotás A, Lombardi VC. Single-nucleotide polymorphisms in a cohort of significantly obese women without cardiometabolic diseases. Int J Obes 43(2):253-262, 2019.
2. Read RW, Schlauch KA, Elhanan G., Metcalf WJ, Slonim AD, Aweti R, Borkowski R, Grzymski JJ, 2019. GWAS and PheWAS of red blood cell components in a Northern Nevadan cohort. PLoS ONE 14, e0218078.
3. Grzymski JJ, Elhanan G, Smith E, Rowan C, Slotnick N, Dabe S, et al. Population Health Genetic Screening for Tier 1 Inherited Diseases in Northern Nevada: 90% of At-Risk Carriers are Missed. bioRxiv, May 27, 2019; doi:https://doi.org/10.1101/650549.Nature Medicine, in review.
4. Cirulli, E.T., White, S., Read, R.W. et al. Genome-wide rare variant analysis for thousands of phenotypes in over 70,000 exomes from two cohorts. Nat Commun 11, 542 (2020). https://doi.org/10.1038/s41467-020-14288-y
5. Schlauch KA, Read RW, Lombardi VC, Elhanan G, Metcalf WJ, Slonim AD, the 23andMe Research Team, Grzymski JJ. A Comprehensive Genome-wide and Phenome-wide Examination of BMI and Obesity in a Northern Nevadan Cohort. doi: https://doi.org/10.1101/671123. G3: Genes, Genomes, Genetics, in press.
6. Bolze A, Mendez F, White S, Tanudjaja F, Isaksson M, Rashkin M, Bowes J, Cirulli ET, Metcalf WJ, Grzymski JJ, Lee W, Lu JT, Washington NJ. Selective constraints and pathogenicity of mitochondrial DNA variants inferred from a novel database of 196,554 unrelated individuals. doi:https://doi.org/10.1101/798264. eLife, in revision.
7. A, Goto K, Ak G, Yoshihawa Y, Emi M, Pastorino S, Carparelli L, Ferro A, Nasu M, Kim J-H, Suarez J, Xu R, Tanji M, Takinishi Y, Minaai M, Novelli F, Pagano I, Gaudino G, Pass H, Groden J, Grzymski J, Metintas M, Akarsu M, Morrow B, Hassan R, Yang H, Carbone M. 2020. Heterozygous germline BLM mutations increase susceptibility to asbestos and mesothelioma. https://doi.org/10.1073/pnas.2019652117. Proc. Natl. Acad. Sci.
8. Bonnefond A, Boissel M, Bolze A, Durand E, Toussaint B, Vaillant E, Gaget S, De Graeve F, Dechaume A, Allegaert F, Le Guilcher D, Yengo L, Dhennin V, Borys J-M, Lu J, Cirulli E, Elhanan G, Roussel R, Balkau B, Marre M, Franc, S, Charpentier G, Vaxillaire M, Canouil M, Washington N, Grzymski J, Frouguel P. 2020. Pathogenic variants in actionable MODY genes are associated with type 2 diabetes. Nature Metabolism volume 2, 1126–1134(2020)

Publication outlining the HNP study

1. Grzymski JJ, Schlauch K, Read R, Metacalf WJ, et al. The Healthy Nevada Project: A Population Health Study of Linked Electronic Health Records, Genomic Data, and Environmental Factors. In Preparation.

Publications targeting EHR data

1. Rosenquist N, Metcalf J; Ryu SY, Field-Ridley A, Coppes MJ, Grzymski JJ, Strickland MJ, Darrow LA: Acute associations between PM2.5 and ozone concentrations and asthma exacerbations among patients with and without allergic comorbidities. DOI: 10.1038/s41370-020-0213-7. J Expo Sci Environ Epidemoil.
2. Field-Ridley A, Rosenquist N, Elhanan G, Joros A, Metcalf J, Coppes M, Strickland M, Darrow L: Exposure to fine particulate matter is associated with health care utilization among infants and children with bronchiolitis, submitted.
3. Kiser D, Metcalf WJ, Elhanan G, Schnieder B, Schlauch K, Joros A, Petersen C, Grzymski JJ. Particulate matter and emergency visits for asthma: a time-series study of their association in the presence and absence of wildfire smoke in Reno, Nevada, 2013–2018. 2020; 19:92. doi: 10.1186/s12940-020-00646-2

Peer-reviewed Abstracts and Presentations (Population Genetics)

1. Grzymski JJ, Slotnick N, Rowan C, Elhanan G, Reed H, Lipp B, Smith E, Metcalf J, Bolze A, Dunaway K, Washington N, Lu J. 2019. American College of Medical Genetics. “Population Health Genetic Screening in Northern Nevada: At-Risk Individuals are Missed Using Current Guidelines”.
2. Schlauch KA, Read RW, Metcalf J, Elhanan G, Rybarski S, Grzymski J. 2018. American Society of Human Genetics. “Published and novel human associations of blood cell traits in the Healthy Nevada Project cohort”.
3. Gai Elhanan, William J Metcalf, Harry Reed, Bruce Lipp, Elizabeth Smith, Nicole Washington, Keith Dunaway, Alex Bolze, Chris Rowan, Nathan Slotnick, James Lu, Joseph J. Grzymski. American Society of Human Genetics 2019. Population-based Genetic Screening: Does diagnostic information enter into the medical record?
4. CJ Rowan, MD, WJ Metcalf, MSc, G Elhanan, MD, AN Joros, MSc, JJ Grzymski, PhD. American Thoracic Society 2018. Short-Term Sentinel Air Events in Relation to Health Care Utilization for Specific Health Conditions in Reno, Nevada.
5. Bolze, S. White, E.T. Cirulli, L. Sharma, K.A. Schlauch, G. Elhanan, J. Grzymski, N.L. Washington, J. Lu. American Society of Human Genetics 2019. A genetic retrospective study of maturity-onset diabetes of the young (MODY) in two population health studies.
6. ET Cirulli, S White, RW Read, G Elhanan, WJ Metcalf, KA Schlauch, JJ Grzymski, J Lu, NL Washington. American society of Human Genetics 2019. Genome-wide rare variant analysis for thousands of phenotypes in 70,000+ exomes.
7. RW Read, KA Schlauch, ET Cirulli, NL Washington, S White, J Lu, A Slonim, JJ Grzymski. American Society of Human Genetics 2019. Validation and discovery of BMI-related variants in a Northern Nevada cohort of the Healthy Nevada Project.
8. JJ Grzymski, RW Read, G Elhanan, WJ Metcalf, KA Schlauch, A Slonim. American Society of Human Genetics 2019. A phenome-wide and genome-wide analysis of triglyceride levels in the Healthy Nevada Project cohort
9. KA Schlauch, RW Read, ET Cirulli, S White, NL Washington, J Lu, A Slonim, JJ Grzymski. American society of Human Genetics 2019. The genetics of addiction in a large Northern Nevada cohort of the Healthy Nevada Project.