NASH STUDY

PARTICIPATE IN THE NASH STUDY

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PARTICIPATE

Renown IHI has begun enrollment for the Nonalcoholic Steatohepatitis Liver Disease Genome Atlas study and is currently available online to Renown patients who have not already participated in the Healthy Nevada Project.

JOIN THE STUDY

On July 11th, 2019, Gilead Sciences, Inc. and the Renown Institute for Health Innovation (IHI) announced a strategic collaboration to collect and analyze de-identified genetic and electronic health data that can enhance the understanding of a type of liver disease called Nonalcoholic Steatohepatitis (NASH) and potentially inform development of treatment options for the disease.

Renown IHI has begun enrollment for the Nonalcoholic Steatohepatitis Liver Disease Genome Atlas study and is currently available online to Renown patients who have not already participated in the Healthy Nevada Project.

This is an observational study trying to understand genetic links to Nonalcoholic Steatohepatitis or NASH and is being performed in conjunction with the Healthy Nevada Project.

De-identified genetic information from the Healthy Nevada Project and de-identified information from a patient’s medical record, such as blood tests or imaging tests, will be used to study NASH.  Some participants may be asked to provide a blood sample or undergo imaging tests so that information can be used for research.  All of the information collected for the study will be stored in a database as de-identified information to ensure patient privacy and adhere to the study’s strict data policies.

Qualified study participants live in northern Nevada and meet at least one of the following criteria: 

  • Renown Patient
  • Type two diabetes
  • Metabolic syndrome and dyslipidemia
  • Elevated liver enzymes or elevated liver function
  • Prediabetes
  • Weight in obese range
  • Family member who has NASH
  • High blood lipids, such as cholesterol and triglycerides
How to Join

HOW TO JOIN

Joining the study is a simple process of 1, 2, 3. Sign the consent form, send back your sample and get your results.

Join The STUDY

If you have any questions about these studies, please email us at RenownIHI@renown.org and our research staff will contact you.

Frequently Asked Questions

Q: What is NAFLD and NASH?

A: Nonalcoholic Fatty Liver Disease (NAFLD) is a build-up of fat in the liver of people who don’t abuse alcohol. It is normal for the liver to contain some fat, but if more than 5 percent of the liver’s weight is fat, it’s considered a fatty liver (steatosis). NASH stands for Nonalcoholic Steatohepatitis and is the most severe form of NAFLD in which you have liver cell damage and hepatitis (inflammation) of the liver.  Inflammation and liver cell damage can cause fibrosis, or scarring of the liver, and can cause decreased liver function (2).  The symptoms for NASH are often silent or non-specific, making it difficult to diagnose.  About one-third of people with NASH develop cirrhosis or irreversible liver damage (1).

Q: How does someone get NASH?

A: There are a number of genes that contribute to Nonalcoholic Steatohepatitis (NASH). If a person has family members who had or currently have NASH or Nonalcoholic Fatty Liver Disease (NAFLD), they may be at risk. Additionally, having certain health conditions may increase a person’s risk to develop NASH. These include: being overweight or obese, having high cholesterol or high triglyceride levels, having type 2 diabetes, and having insulin resistance or prediabetes (3).

Q: How common is NAFLD and NASH

A: Nonalcoholic Fatty Liver Disease (NAFLD) is the most common chronic liver condition in the United States. Although the condition is thought to be under- diagnosed and estimates very, it is predicted that 1 out of 4 adults in the U.S have NAFLD. Of those with NAFLD, about 20 percent have Nonalcoholic Steatohepatitis (NASH) (2).  That equates to approximately 2-5% of adults in the U.S. or 6.5 – 16.3 million people who may have NASH (2).

Q: Are there treatments for NAFLD and NASH?

A: We are asking participants to consider being a part of this study to help us learn why some people develop a type of liver disease called Nonalcoholic Steatohepatitis (NASH) and why some people do not. There are currently no accepted FDA approved drugs to treat NASH, and we need volunteers at various risk for the disease to develop new treatments. By analyzing genetic information from participation in the Healthy Nevada Project and medical record information, we hope to be able to develop new therapies and treatments for the disease.

Q: What can I expect if I participate in the Nonalcoholic Steatohepatitis Liver Disease Genome Atlas study?

A: If you have not participated in the Healthy Nevada Project, you will be asked to join as an inclusion criteria for participation in this study. The Healthy Nevada Project is a clinical research study that provides de-identified genetic data that can be used for research using a small saliva sample. You will be asked to go through the consent process for the Healthy Nevada Project if you are not already enrolled in the project.

As a participant in this study, you will be asked to allow us access to your medical information to be used in a de-identified data set for research and development, and associate that information with your de-identified genetic information in our joint genetic and health information database. You may be periodically contacted via email with important information, such as new research developments, surveys, insights or opportunities being offered to participants.

It is possible that you may be asked to provide a blood sample which will be used in an enhanced liver fibrosis (ELF) test or similar diagnostic test, or asked to have an imaging test performed, such as elastography or liver elastography, that checks the liver for fibrosis. Not all participants will be asked to undergo these tests, and if you are asked, they can be conducted at your convenience.

Q: Is there any cost associated with being in this study?

A: Participation in this research study is offered at no cost.  Participants receive no-cost genetic sequencing, ancestry, and wellness insights through the Healthy Nevada Project. As a participant in the Nonalcoholic Steatohepatitis Liver Disease Genome Atlas study, any tests requested as a component of the research study, such as blood or imaging tests, will also be provided at no cost.

If you are asked to provide a blood sample or have imaging performed, you will be provided with clinical diagnostic information from these tests. The results of the tests will be put in your medical record and will be available to your doctor to help direct your care. Visits to your doctor, whether directly or indirectly related to this study, are not covered.

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